Setting description

Taxel therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Niraparib
— param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
–+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
-+- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
-++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+– param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+-+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
++- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
+++ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Niraparib
all param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TP53- param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TP53+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
DRD+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.024, shape = 1.3
summary mean = 39, median = 31.9 mean = 39, median = 31.9 mean = 70.5, median = 57.5 mean = 39, median = 31.9
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.8, hr = 0.46 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 376 0
TP53- 4 360 0
TP53+ 1 359 2
DRD+ 1 167 1
TEfus+ 1 329 0
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.752 0.000
TP53- 0.008 0.720 0.000
TP53+ 0.002 0.718 0.004
DRD+ 0.002 0.334 0.002
TEfus+ 0.002 0.658 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 212 0 233
TP53- 361 2 370
TP53+ 325 7 334
DRD+ 185 4 314
TEfus+ 245 1 298
Hormone_therapies Taxel_therapies Niraparib
all 0.424 0.000 0.466
TP53- 0.722 0.004 0.740
TP53+ 0.650 0.014 0.668
DRD+ 0.370 0.008 0.628
TEfus+ 0.490 0.002 0.596
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Niraparib
all 0 0 0
TP53- 27 65 23
TP53+ 8 23 2
DRD+ 0 0 0
TEfus+ 0 0 0
Hormone_therapies Taxel_therapies Niraparib
all 0.000 0.000 0.000
TP53- 0.054 0.130 0.046
TP53+ 0.016 0.046 0.004
DRD+ 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000


Errors & power

The overall error was 0.216.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.014             0.204             0.006

The overall power was 0.752.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies         Niraparib 
            0.000             0.752             0.000

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Niraparib
all graduation 0 0 376 0
futility 0 212 0 233
max_n 0 0 0 0
n 634 (460, 744) 236 (116, 401) 340 (176, 543) 224 (117, 388)
n_unique 634 (460, 744) 236 (116, 401) 340 (176, 543) 224 (117, 388)
time_trial 60 (60, 60) 60 (29, 60) 42 (22, 60) 60 (26, 60)
time_stop NA (NA, NA) 39 (20, 55) 36 (20, 54) 39 (20, 57)
post_p NA (NA, NA) 0.02 (0, 0.17) 1 (1, 1) 0.02 (0, 0.15)
rate 0.017 (0.016, 0.018) 0.022 (0.019, 0.025) 0.01 (0.009, 0.012) 0.022 (0.019, 0.025)
TP53- graduation 0 4 360 0
futility 0 361 2 370
max_n 0 27 65 23
n 347 (205, 423) 114 (53, 275) 178 (84, 302) 101 (51, 257)
n_unique 347 (205, 423) 114 (53, 275) 178 (84, 302) 101 (51, 257)
time_trial 60 (60, 60) 39 (20, 60) 43 (22, 60) 37 (20, 60)
time_stop NA (NA, NA) 32 (19, 52) 36 (20, 53) 31 (19, 52)
post_p NA (NA, NA) 0.05 (0, 0.37) 1 (0.98, 1) 0.07 (0, 0.34)
rate 0.017 (0.015, 0.019) 0.022 (0.019, 0.027) 0.011 (0.009, 0.012) 0.022 (0.019, 0.027)
TP53+ graduation 0 1 359 2
futility 0 325 7 334
max_n 0 8 23 2
n 299 (189, 352) 91 (50, 222) 152 (79, 277) 88 (50, 207)
n_unique 299 (189, 352) 91 (50, 222) 152 (79, 277) 88 (50, 207)
time_trial 60 (60, 60) 44 (25, 60) 43 (22, 60) 45 (23, 60)
time_stop NA (NA, NA) 35 (24, 51) 35 (20, 54) 34 (21, 53)
post_p NA (NA, NA) 0.07 (0, 0.37) 1 (0.98, 1) 0.07 (0, 0.33)
rate 0.017 (0.015, 0.019) 0.022 (0.018, 0.027) 0.01 (0.009, 0.013) 0.022 (0.018, 0.027)
DRD+ graduation 0 1 167 1
futility 0 185 4 314
max_n 0 0 0 0
n 164 (109, 205) 62 (32, 119) 64 (31, 120) 73 (50, 131)
n_unique 164 (109, 205) 62 (32, 119) 64 (31, 120) 73 (50, 131)
time_trial 60 (60, 60) 60 (37, 60) 60 (36, 60) 45 (21, 60)
time_stop NA (NA, NA) 43 (30, 55) 43 (29, 57) 33 (19, 51)
post_p NA (NA, NA) 0.12 (0.01, 0.5) 0.99 (0.86, 1) 0.1 (0.01, 0.43)
rate 0.017 (0.015, 0.02) 0.022 (0.017, 0.028) 0.01 (0.008, 0.014) 0.022 (0.019, 0.027)
TEfus+ graduation 0 1 329 0
futility 0 245 1 298
max_n 0 0 0 0
n 218 (146, 272) 82 (41, 162) 108 (57, 189) 74 (47, 161)
n_unique 218 (146, 272) 82 (41, 162) 108 (57, 189) 74 (47, 161)
time_trial 60 (60, 60) 60 (29, 60) 48 (25, 60) 50 (24, 60)
time_stop NA (NA, NA) 36 (26, 52) 38 (23, 55) 34 (23, 55)
post_p NA (NA, NA) 0.11 (0.01, 0.44) 1 (0.94, 1) 0.09 (0, 0.4)
rate 0.017 (0.015, 0.02) 0.022 (0.018, 0.027) 0.01 (0.008, 0.013) 0.022 (0.019, 0.028)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Niraparib
— graduation 0 386 438 395
futility 0 0 0 0
max_n 0 27 46 23
n 198 (115, 247) 56 (23, 160) 105 (51, 195) 44 (13, 155)
n_unique 198 (115, 247) 56 (23, 160) 105 (51, 195) 44 (13, 155)
post_p NA (NA, NA) 0.13 (0.01, 0.5) 1 (0.9, 1) 0.17 (0.01, 0.53)
rate 0.017 (0.015, 0.02) 0.022 (0.018, 0.029) 0.011 (0.009, 0.013) 0.022 (0.017, 0.031)
–+ graduation 0 415 449 432
futility 0 0 0 0
max_n 0 27 42 21
n 52 (29, 73) 17 (6, 49) 27 (13, 53) 14 (5, 48)
n_unique 52 (29, 73) 17 (6, 49) 27 (13, 53) 14 (5, 48)
post_p NA (NA, NA) 0.28 (0.06, 0.65) 0.91 (0.59, 0.99) 0.27 (0.07, 0.68)
rate 0.017 (0.013, 0.022) 0.023 (0.015, 0.036) 0.011 (0.007, 0.016) 0.023 (0.015, 0.039)
-+- graduation 0 371 426 379
futility 0 0 0 0
max_n 0 8 22 2
n 134 (83, 161) 33 (12, 106) 72 (34, 139) 30 (10, 101)
n_unique 134 (83, 161) 33 (12, 106) 72 (34, 139) 30 (10, 101)
post_p NA (NA, NA) 0.15 (0.02, 0.54) 0.99 (0.81, 1) 0.2 (0.02, 0.6)
rate 0.017 (0.014, 0.02) 0.023 (0.018, 0.032) 0.011 (0.008, 0.014) 0.022 (0.016, 0.033)
-++ graduation 0 410 451 430
futility 0 0 0 0
max_n 0 8 21 2
n 87 (50, 115) 25 (9, 77) 46 (23, 91) 20 (8, 70)
n_unique 87 (50, 115) 25 (9, 77) 46 (23, 91) 20 (8, 70)
post_p NA (NA, NA) 0.25 (0.03, 0.62) 0.96 (0.75, 1) 0.22 (0.03, 0.59)
rate 0.017 (0.014, 0.021) 0.022 (0.016, 0.032) 0.011 (0.007, 0.014) 0.023 (0.016, 0.036)
+– graduation 0 416 445 436
futility 0 0 0 0
max_n 0 24 44 22
n 48 (26, 64) 16 (5, 43) 18 (7, 40) 19 (10, 46)
n_unique 48 (26, 64) 16 (5, 43) 18 (7, 40) 19 (10, 46)
post_p NA (NA, NA) 0.28 (0.06, 0.68) 0.86 (0.5, 0.98) 0.24 (0.05, 0.65)
rate 0.017 (0.013, 0.023) 0.022 (0.015, 0.038) 0.01 (0.006, 0.017) 0.023 (0.016, 0.033)
+-+ graduation 0 438 455 453
futility 0 0 0 0
max_n 0 24 40 20
n 43 (25, 62) 15 (5, 42) 18 (6, 38) 17 (9, 45)
n_unique 43 (25, 62) 15 (5, 42) 18 (6, 38) 17 (9, 45)
post_p NA (NA, NA) 0.29 (0.06, 0.7) 0.86 (0.5, 0.98) 0.26 (0.04, 0.68)
rate 0.017 (0.013, 0.023) 0.023 (0.014, 0.038) 0.01 (0.006, 0.017) 0.023 (0.016, 0.035)
++- graduation 0 402 431 428
futility 0 0 0 0
max_n 0 8 22 2
n 37 (22, 51) 13 (4, 34) 13 (4, 32) 16 (7, 36)
n_unique 37 (22, 51) 13 (4, 34) 13 (4, 32) 16 (7, 36)
post_p NA (NA, NA) 0.29 (0.08, 0.67) 0.82 (0.41, 0.97) 0.28 (0.06, 0.66)
rate 0.017 (0.012, 0.023) 0.023 (0.014, 0.039) 0.01 (0.005, 0.018) 0.023 (0.015, 0.033)
+++ graduation 0 433 455 454
futility 0 0 0 0
max_n 0 8 21 2
n 34 (20, 49) 13 (4, 35) 12 (4, 30) 15 (7, 38)
n_unique 34 (20, 49) 13 (4, 35) 12 (4, 30) 15 (7, 38)
post_p NA (NA, NA) 0.32 (0.07, 0.7) 0.82 (0.48, 0.96) 0.3 (0.06, 0.67)
rate 0.018 (0.012, 0.023) 0.023 (0.014, 0.038) 0.01 (0.005, 0.019) 0.023 (0.015, 0.038)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Niraparib
all count 376
time_stop 36 (20, 54)
n_trt 290 (170, 479)
n_control 428 (223, 622)
post_p 1 (0.98, 1)
order 2 (1, 3)
TP53- count 4 360
time_stop 14 (12, 24) 36 (20, 53)
n_trt 62 (51, 104) 156 (80, 279)
n_control 80 (63, 123) 220 (123, 351)
post_p 0.9 (0.88, 0.94) 1 (0.94, 1)
order 1 (1, 1) 2 (1, 4)
TP53+ count 1 359 2
time_stop 39 (39, 39) 35 (21, 54) 24 (22, 26)
n_trt 94 (94, 94) 131 (79, 220) 74 (69, 78)
n_control 190 (190, 190) 178 (106, 276) 116 (109, 124)
post_p 0.92 (0.92, 0.92) 0.99 (0.93, 1) 0.96 (0.95, 0.98)
order 2 (2, 2) 2 (1, 4) 1 (1, 1)
DRD+ count 1 167 1
time_stop 30 (30, 30) 44 (29, 57) 23 (23, 23)
n_trt 59 (59, 59) 69 (52, 116) 66 (66, 66)
n_control 96 (96, 96) 134 (87, 180) 76 (76, 76)
post_p 0.98 (0.98, 0.98) 0.98 (0.95, 1) 0.97 (0.97, 0.97)
order 1 (1, 1) 4 (2, 5) 1 (1, 1)
TEfus+ count 1 329
time_stop 18 (18, 18) 38 (23, 55)
n_trt 50 (50, 50) 102 (61, 168)
n_control 72 (72, 72) 157 (91, 232)
post_p 0.95 (0.95, 0.95) 0.99 (0.95, 1)
order 1 (1, 1) 3 (1, 5)
Futility:
signature var Hormone_therapies Taxel_therapies Niraparib
all count 212 233
time_stop 39 (20, 55) 39 (20, 57)
n_trt 160 (90, 294) 161 (92, 291)
n_control 432 (227, 617) 427 (233, 638)
post_p 0.01 (0, 0.1) 0.01 (0, 0.08)
order 5 (1, 8) 4 (1, 7)
TP53- count 361 2 370
time_stop 32 (19, 52) 18 (16, 21) 31 (19, 52)
n_trt 91 (54, 196) 74 (61, 86) 88 (52, 190)
n_control 204 (113, 342) 108 (90, 127) 195 (109, 343)
post_p 0.11 (0.02, 0.24) 0.21 (0.21, 0.22) 0.09 (0.02, 0.22)
order 3 (1, 6) 1.5 (1.1, 1.9) 2 (1, 6)
TP53+ count 325 7 334
time_stop 35 (23, 51) 16 (14, 19) 34 (21, 53)
n_trt 79 (52, 152) 58 (51, 69) 80 (51, 172)
n_control 183 (118, 279) 75 (66, 95) 176 (102, 291)
post_p 0.11 (0.02, 0.25) 0.17 (0.08, 0.28) 0.09 (0.02, 0.24)
order 3 (1, 6) 1 (1, 1) 3 (1, 6.7)
DRD+ count 185 4 314
time_stop 43 (31, 55) 34 (27, 43) 33 (19, 51)
n_trt 64 (50, 104) 58 (52, 64) 66 (51, 107)
n_control 135 (95, 178) 116 (81, 148) 104 (60, 163)
post_p 0.1 (0.02, 0.26) 0.22 (0.21, 0.27) 0.1 (0.02, 0.23)
order 5 (3, 8) 3 (1.3, 4.7) 3 (1, 7)
TEfus+ count 245 1 298
time_stop 36 (26, 53) 20 (20, 20) 34 (23, 55)
n_trt 72 (52, 126) 55 (55, 55) 68 (51, 125)
n_control 157 (106, 224) 90 (90, 90) 146 (92, 229)
post_p 0.12 (0.03, 0.24) 0.27 (0.27, 0.27) 0.09 (0.02, 0.23)
order 4 (2, 8) 1 (1, 1) 4 (1, 7)


By subgroup combinations

Graduation:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Taxel_therapies count 376 376 376 376 376 376 376 376
time 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54) 36 (20, 54)
n 94 (48, 178) 25 (12, 48) 65 (33, 116) 41 (22, 76) 17 (6, 36) 15 (6, 34) 12 (4, 27) 10 (4, 25)
post_p 0.94 (0.67, 1) 0.8 (0.59, 0.97) 0.91 (0.62, 1) 0.87 (0.62, 0.99) 0.72 (0.57, 0.93) 0.71 (0.56, 0.94) 0.69 (0.57, 0.9) 0.69 (0.57, 0.9)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.005, 0.012) 0.009 (0.002, 0.014) 0.009 (0.005, 0.013) 0.009 (0.004, 0.013) 0.007 (0, 0.013) 0.008 (0, 0.014) 0.006 (0, 0.013) 0.007 (0, 0.015)
TP53- Hormone_therapies count 4 4 4 4
time 14 (12, 24) 14 (12, 24) 14 (12, 24) 14 (12, 24)
n 43 (34, 61) 11 (6, 26) 6 (2, 7) 6 (4, 11)
post_p 0.76 (0.73, 0.78) 0.73 (0.63, 0.8) 0.66 (0.62, 0.74) 0.63 (0.61, 0.7)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.007 (0.005, 0.011) 0.003 (0, 0.009) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 360 360 360 360
time 36 (20, 53) 36 (20, 53) 36 (20, 53) 36 (20, 53)
n 92 (49, 172) 25 (13, 47) 18 (6, 36) 15 (6, 34)
post_p 0.95 (0.74, 1) 0.81 (0.71, 0.97) 0.75 (0.63, 0.92) 0.74 (0.63, 0.93)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.004, 0.012) 0.008 (0.002, 0.013) 0.006 (0, 0.012) 0.007 (0, 0.012)
TP53+ Hormone_therapies count 1 1 1 1
time 39 (39, 39) 39 (39, 39) 39 (39, 39) 39 (39, 39)
n 33 (33, 33) 32 (32, 32) 12 (12, 12) 17 (17, 17)
post_p 0.71 (0.71, 0.71) 0.73 (0.73, 0.73) 0.76 (0.76, 0.76) 0.82 (0.82, 0.82)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.01 (0.01, 0.01) 0.015 (0.015, 0.015) 0.011 (0.011, 0.011) 0.012 (0.012, 0.012)
Taxel_therapies count 359 359 359 359
time 35 (21, 54) 35 (21, 54) 35 (21, 54) 35 (21, 54)
n 65 (34, 116) 41 (24, 74) 11 (4, 27) 10 (5, 26)
post_p 0.91 (0.74, 1) 0.86 (0.72, 0.98) 0.72 (0.62, 0.9) 0.72 (0.62, 0.9)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.009 (0.005, 0.012) 0.009 (0.003, 0.013) 0.005 (0, 0.012) 0.006 (0, 0.013)
Niraparib count 2 2 2 2
time 24 (22, 26) 24 (22, 26) 24 (22, 26) 24 (22, 26)
n 18 (15, 22) 22 (20, 24) 20 (18, 21) 14 (9, 18)
post_p 0.76 (0.72, 0.81) 0.8 (0.75, 0.85) 0.75 (0.73, 0.77) 0.73 (0.68, 0.78)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.011 (0.01, 0.011) 0.003 (0.001, 0.006) 0.014 (0.013, 0.015) 0.002 (0, 0.004)
DRD+ Hormone_therapies count 1 1 1 1
time 30 (30, 30) 30 (30, 30) 30 (30, 30) 30 (30, 30)
n 10 (10, 10) 23 (23, 23) 13 (13, 13) 13 (13, 13)
post_p 0.61 (0.61, 0.61) 0.88 (0.88, 0.88) 0.71 (0.71, 0.71) 0.78 (0.78, 0.78)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.017 (0.017, 0.017) 0.004 (0.004, 0.004) 0.007 (0.007, 0.007) 0 (0, 0)
Taxel_therapies count 167 167 167 167
time 44 (29, 57) 44 (29, 57) 44 (29, 57) 44 (29, 57)
n 21 (12, 35) 22 (9, 35) 15 (6, 28) 16 (7, 27)
post_p 0.82 (0.71, 0.96) 0.78 (0.7, 0.96) 0.79 (0.66, 0.93) 0.77 (0.64, 0.94)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.007 (0.002, 0.012) 0.008 (0, 0.013) 0.006 (0, 0.012) 0.007 (0, 0.012)
Niraparib count 1 1 1 1
time 23 (23, 23) 23 (23, 23) 23 (23, 23) 23 (23, 23)
n 16 (16, 16) 15 (15, 15) 14 (14, 14) 21 (21, 21)
post_p 0.76 (0.76, 0.76) 0.71 (0.71, 0.71) 0.82 (0.82, 0.82) 0.87 (0.87, 0.87)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.006 (0.006, 0.006) 0.014 (0.014, 0.014) 0.013 (0.013, 0.013) 0.007 (0.007, 0.007)
TEfus+ Hormone_therapies count 1 1 1 1
time 18 (18, 18) 18 (18, 18) 18 (18, 18) 18 (18, 18)
n 4 (4, 4) 29 (29, 29) 9 (9, 9) 8 (8, 8)
post_p 0.6 (0.6, 0.6) 0.81 (0.81, 0.81) 0.66 (0.66, 0.66) 0.66 (0.66, 0.66)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 329 329 329 329
time 38 (23, 55) 38 (23, 55) 38 (23, 55) 38 (23, 55)
n 26 (14, 46) 43 (25, 77) 16 (6, 34) 12 (5, 27)
post_p 0.82 (0.72, 0.97) 0.88 (0.72, 0.99) 0.75 (0.64, 0.93) 0.75 (0.63, 0.92)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.008 (0.003, 0.013) 0.009 (0.004, 0.013) 0.007 (0, 0.013) 0.006 (0, 0.013)
Futility:
signature treatment var — –+ -+- -++ +– +-+ ++- +++
all Hormone_therapies count 212 212 212 212 212 212 212 212
time 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55) 39 (20, 55)
n 42 (21, 111) 14 (5, 34) 24 (10, 69) 20 (6, 50) 13 (4, 30) 12 (4, 27) 9 (3, 24) 10 (3, 19)
post_p 0.2 (0.03, 0.43) 0.31 (0.1, 0.46) 0.24 (0.04, 0.44) 0.28 (0.06, 0.46) 0.31 (0.1, 0.48) 0.32 (0.12, 0.48) 0.34 (0.13, 0.48) 0.32 (0.09, 0.47)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.016, 0.03) 0.022 (0.014, 0.041) 0.022 (0.016, 0.036) 0.022 (0.015, 0.036) 0.022 (0.013, 0.042) 0.022 (0.013, 0.04) 0.022 (0.013, 0.046) 0.024 (0.013, 0.046)
Niraparib count 233 233 233 233 233 233 233 233
time 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57) 39 (20, 57)
n 31 (12, 91) 11 (4, 31) 21 (6, 65) 16 (7, 45) 16 (9, 36) 16 (9, 32) 13 (7, 29) 13 (7, 30)
post_p 0.22 (0.05, 0.47) 0.3 (0.09, 0.47) 0.28 (0.06, 0.46) 0.28 (0.05, 0.47) 0.26 (0.07, 0.47) 0.3 (0.08, 0.48) 0.3 (0.07, 0.47) 0.32 (0.09, 0.46)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.015, 0.033) 0.024 (0.014, 0.042) 0.021 (0.015, 0.037) 0.022 (0.014, 0.036) 0.023 (0.015, 0.034) 0.022 (0.015, 0.036) 0.022 (0.015, 0.037) 0.023 (0.015, 0.038)
TP53- Hormone_therapies count 361 361 361 361
time 32 (19, 52) 32 (19, 52) 32 (19, 52) 32 (19, 52)
n 47 (23, 118) 15 (6, 37) 14 (5, 35) 13 (5, 33)
post_p 0.24 (0.04, 0.45) 0.33 (0.12, 0.47) 0.35 (0.14, 0.48) 0.35 (0.13, 0.48)
r_prob 0.37 (0.37, 0.37) 0.19 (0.19, 0.19) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.028) 0.021 (0.013, 0.039) 0.021 (0.012, 0.038) 0.021 (0.013, 0.039)
Taxel_therapies count 2 2 2 2
time 18 (16, 21) 18 (16, 21) 18 (16, 21) 18 (16, 21)
n 51 (37, 65) 8 (8, 9) 8 (7, 8) 6 (6, 7)
post_p 0.33 (0.26, 0.4) 0.34 (0.21, 0.46) 0.38 (0.35, 0.41) 0.41 (0.34, 0.48)
r_prob 0.25 (0.25, 0.25) 0.38 (0.38, 0.38) 0 (0, 0) 0 (0, 0)
rate 0.014 (0.01, 0.017) 0.025 (0.015, 0.036) 0.021 (0.021, 0.022) 0.02 (0.015, 0.024)
Niraparib count 370 370 370 370
time 31 (19, 52) 31 (19, 52) 31 (19, 52) 31 (19, 52)
n 37 (14, 108) 13 (5, 32) 17 (9, 37) 16 (9, 31)
post_p 0.3 (0.06, 0.48) 0.34 (0.12, 0.48) 0.32 (0.09, 0.48) 0.34 (0.1, 0.48)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.019 (0.013, 0.03) 0.021 (0.012, 0.042) 0.021 (0.013, 0.034) 0.021 (0.014, 0.035)
TP53+ Hormone_therapies count 325 325 325 325
time 35 (23, 51) 35 (23, 51) 35 (23, 51) 35 (23, 51)
n 30 (13, 71) 24 (10, 51) 11 (4, 26) 11 (4, 24)
post_p 0.27 (0.04, 0.47) 0.31 (0.09, 0.47) 0.36 (0.16, 0.48) 0.35 (0.13, 0.48)
r_prob 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.02 (0.015, 0.032) 0.02 (0.014, 0.031) 0.021 (0.013, 0.045) 0.022 (0.013, 0.046)
Taxel_therapies count 7 7 7 7
time 16 (14, 19) 16 (14, 19) 16 (14, 19) 16 (14, 19)
n 27 (25, 40) 19 (11, 26) 4 (3, 11) 3 (2, 6)
post_p 0.31 (0.27, 0.42) 0.44 (0.3, 0.48) 0.36 (0.22, 0.45) 0.3 (0.27, 0.41)
r_prob 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.019 (0.015, 0.021) 0.011 (0.007, 0.026) 0.029 (0.007, 0.074) 0.048 (0.016, 0.065)
Niraparib count 334 334 334 334
time 34 (21, 53) 34 (21, 53) 34 (21, 53) 34 (21, 53)
n 26 (10, 81) 19 (8, 55) 15 (8, 29) 14 (7, 31)
post_p 0.3 (0.06, 0.47) 0.31 (0.08, 0.47) 0.34 (0.11, 0.47) 0.37 (0.1, 0.49)
r_prob 0 (0, 0) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.02 (0.013, 0.031) 0.021 (0.013, 0.037) 0.022 (0.014, 0.035) 0.021 (0.014, 0.039)
DRD+ Hormone_therapies count 185 185 185 185
time 43 (31, 55) 43 (31, 55) 43 (31, 55) 43 (31, 55)
n 20 (7, 40) 18 (6, 40) 14 (5, 28) 15 (5, 28)
post_p 0.31 (0.09, 0.48) 0.34 (0.1, 0.48) 0.32 (0.13, 0.47) 0.32 (0.08, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.014, 0.032) 0.021 (0.014, 0.034) 0.021 (0.014, 0.037) 0.023 (0.015, 0.039)
Taxel_therapies count 4 4 4 4
time 34 (27, 43) 34 (27, 43) 34 (27, 43) 34 (27, 43)
n 24 (15, 29) 14 (5, 26) 13 (7, 14) 7 (3, 14)
post_p 0.39 (0.38, 0.41) 0.34 (0.27, 0.42) 0.42 (0.38, 0.44) 0.44 (0.39, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.013 (0.011, 0.017) 0.025 (0.017, 0.039) 0.016 (0.013, 0.021) 0.024 (0.017, 0.041)
Niraparib count 314 314 314 314
time 33 (19, 51) 33 (19, 51) 33 (19, 51) 33 (19, 51)
n 18 (9, 36) 17 (10, 33) 15 (7, 29) 14 (7, 31)
post_p 0.33 (0.1, 0.48) 0.32 (0.09, 0.48) 0.36 (0.1, 0.48) 0.33 (0.11, 0.48)
r_prob 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.021 (0.013, 0.033) 0.021 (0.014, 0.034) 0.021 (0.013, 0.035) 0.022 (0.014, 0.038)
TEfus+ Hormone_therapies count 245 245 245 245
time 36 (26, 53) 36 (26, 53) 36 (26, 53) 36 (26, 53)
n 18 (7, 37) 26 (12, 61) 15 (6, 32) 12 (5, 26)
post_p 0.31 (0.12, 0.47) 0.31 (0.09, 0.47) 0.34 (0.11, 0.47) 0.35 (0.1, 0.48)
r_prob 0.19 (0.19, 0.19) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.021 (0.015, 0.038) 0.02 (0.015, 0.029) 0.021 (0.013, 0.036) 0.022 (0.013, 0.045)
Taxel_therapies count 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 20 (20, 20) 19 (19, 19) 8 (8, 8) 8 (8, 8)
post_p 0.48 (0.48, 0.48) 0.31 (0.31, 0.31) 0.41 (0.41, 0.41) 0.35 (0.35, 0.35)
r_prob 0.38 (0.38, 0.38) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0)
rate 0.008 (0.008, 0.008) 0.015 (0.015, 0.015) 0.014 (0.014, 0.014) 0.014 (0.014, 0.014)
Niraparib count 298 298 298 298
time 34 (23, 55) 34 (23, 55) 34 (23, 55) 34 (23, 55)
n 13 (5, 33) 20 (8, 55) 17 (10, 34) 15 (8, 30)
post_p 0.31 (0.1, 0.48) 0.3 (0.07, 0.46) 0.31 (0.1, 0.48) 0.34 (0.1, 0.49)
r_prob 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5)
rate 0.022 (0.014, 0.041) 0.02 (0.014, 0.036) 0.021 (0.014, 0.036) 0.022 (0.014, 0.036)